160 American drivers have entered the Formula 1 World Championship. 15 have won a race, led by Mario Andretti with 12 wins.
| # | Driver | Wins | Starts |
|---|---|---|---|
| P1 | Mario Andretti | 12 | 131 |
| P2 | Dan Gurney | 4 | 87 |
| P3 | Phil Hill | 3 | 52 |
| P4 | Peter Revson | 2 | 32 |
| P5 | Bill Vukovich | 2 | 5 |
| P6 | Richie Ginther | 1 | 54 |
| P7 | Rodger Ward | 1 | 12 |
| P8 | Jim Rathmann | 1 | 10 |
| P9 | Jimmy Bryan | 1 | 9 |
| P10 | Johnnie Parsons | 1 | 9 |
| P11 | Troy Ruttman | 1 | 9 |
| P12 | Sam Hanks | 1 | 8 |
| P13 | Pat Flaherty | 1 | 6 |
| P14 | Bob Sweikert | 1 | 5 |
| P15 | Lee Wallard | 1 | 2 |